nonlinear continuous time model Search Results


markovian model for evolutionary change  (Sinsheimer Laboratories)
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Sinsheimer Laboratories markovian model for evolutionary change
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demographic analysis of continuous-time life-history models  (Sinauer Associates Inc)
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Sinauer Associates Inc demographic analysis of continuous-time life-history models
Demographic Analysis Of Continuous Time Life History Models, supplied by Sinauer Associates Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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non-fragile finite-time filter design for time-delayed markovian jump systems via tcs fuzzy model approach  (Nonlinear Dynamics)
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Nonlinear Dynamics non-fragile finite-time filter design for time-delayed markovian jump systems via tcs fuzzy model approach
Non Fragile Finite Time Filter Design For Time Delayed Markovian Jump Systems Via Tcs Fuzzy Model Approach, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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linear time-invariant model  (Nonlinear Dynamics)
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Nonlinear Dynamics linear time-invariant model
Linear Time Invariant Model, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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identification of parametric models from experimental datas  (Verlag GmbH)
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Verlag GmbH identification of parametric models from experimental datas
Identification Of Parametric Models From Experimental Datas, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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empirical modelling of money demand  (Verlag GmbH)
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Verlag GmbH empirical modelling of money demand
Empirical Modelling Of Money Demand, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nonlinear, time-dependent signal transduction model for apoptosis  (Mager Scientific)
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Mager Scientific nonlinear, time-dependent signal transduction model for apoptosis
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Nonlinear, Time Dependent Signal Transduction Model For Apoptosis, supplied by Mager Scientific, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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panel and time series models  (Nonlinear Dynamics)
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Nonlinear Dynamics panel and time series models
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Panel And Time Series Models, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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time-space fractional soliton neuron model (tsfsnm)  (Nonlinear Dynamics)
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Nonlinear Dynamics time-space fractional soliton neuron model (tsfsnm)
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Time Space Fractional Soliton Neuron Model (Tsfsnm), supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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continuous-time plant model  (Nonlinear Dynamics)
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Nonlinear Dynamics continuous-time plant model
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Continuous Time Plant Model, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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garch model  (Nonlinear Dynamics)
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Nonlinear Dynamics garch model
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Garch Model, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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discrete-time model  (Nonlinear Dynamics)
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Nonlinear Dynamics discrete-time model
Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)
Discrete Time Model, supplied by Nonlinear Dynamics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming That Enhances Nanocarrier Deposition and Efficacy

doi: 10.1124/jpet.112.199109

Figure Lengend Snippet: Studies from which data were extracted for in silico PK/PD analysis of combination chemotherapy with Cre-pac (Taxol) and SSL-DXR (Doxil)

Article Snippet: Therefore, a nonlinear, time-dependent signal transduction model for apoptosis was used ( Mager and Jusko, 2001 ) that included three transit compartments.

Techniques: In Silico, Formulation, Clinical Proteomics, Concentration Assay

Schematic of the PK/PD model for combination chemotherapy with Cre-pac and SSL-DXR in various combinations. Symbols, parameters, and corresponding equations are reported in Materials and Methods, Tables 1 and ​and2,2, and Supplemental Data. PK was captured using a CMDD model for Cre-pac (green) and a three-compartment model for SSL-DXR (yellow), incorporating linear release of drug from liposomes (Ait-Oudhia et al., 2012). Free plasma concentrations and blood flow (Q) were used to estimate Kp of drugs from plasma to tumor (blue; Kp-PAC and Kp_DXR). Apoptotic signals (orange for Cre-pac, pink for SSL-DXR) elicited by each agent were driven by their observed intratumor concentrations in a delayed, nonlinear, time-dependent manner. Tumor growth inhibition is modeled with the two transit compartments (gray; R1, dividing tumor cells; R2, cells committed to death), with a first-order growth rate constant (Kg). The cytotoxic effects of each agent (α and β) determine the magnitude of tumor cell death (τd). Red dashed arrow denotes feedback loop capturing the priming effect of PAC-induced apoptosis that alters SSL-DXR deposition (Kp_DXR).

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming That Enhances Nanocarrier Deposition and Efficacy

doi: 10.1124/jpet.112.199109

Figure Lengend Snippet: Schematic of the PK/PD model for combination chemotherapy with Cre-pac and SSL-DXR in various combinations. Symbols, parameters, and corresponding equations are reported in Materials and Methods, Tables 1 and ​and2,2, and Supplemental Data. PK was captured using a CMDD model for Cre-pac (green) and a three-compartment model for SSL-DXR (yellow), incorporating linear release of drug from liposomes (Ait-Oudhia et al., 2012). Free plasma concentrations and blood flow (Q) were used to estimate Kp of drugs from plasma to tumor (blue; Kp-PAC and Kp_DXR). Apoptotic signals (orange for Cre-pac, pink for SSL-DXR) elicited by each agent were driven by their observed intratumor concentrations in a delayed, nonlinear, time-dependent manner. Tumor growth inhibition is modeled with the two transit compartments (gray; R1, dividing tumor cells; R2, cells committed to death), with a first-order growth rate constant (Kg). The cytotoxic effects of each agent (α and β) determine the magnitude of tumor cell death (τd). Red dashed arrow denotes feedback loop capturing the priming effect of PAC-induced apoptosis that alters SSL-DXR deposition (Kp_DXR).

Article Snippet: Therefore, a nonlinear, time-dependent signal transduction model for apoptosis was used ( Mager and Jusko, 2001 ) that included three transit compartments.

Techniques: Liposomes, Clinical Proteomics, Inhibition

Pharmacokinetic and pharmacodynamic parameters and coefficients of variations The mean residence time (MRT) for sterically stabilized liposome doxorubicin (SSL-DXR), calculated as MRT = V ss_DXR /CL DXR with V SS_DXR = V DRX +V p_DXR , was ∼42 h.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Systems Pharmacological Analysis of Paclitaxel-Mediated Tumor Priming That Enhances Nanocarrier Deposition and Efficacy

doi: 10.1124/jpet.112.199109

Figure Lengend Snippet: Pharmacokinetic and pharmacodynamic parameters and coefficients of variations The mean residence time (MRT) for sterically stabilized liposome doxorubicin (SSL-DXR), calculated as MRT = V ss_DXR /CL DXR with V SS_DXR = V DRX +V p_DXR , was ∼42 h.

Article Snippet: Therefore, a nonlinear, time-dependent signal transduction model for apoptosis was used ( Mager and Jusko, 2001 ) that included three transit compartments.

Techniques: Drug discovery, Binding Assay, Clinical Proteomics, Concentration Assay